Background: Vertebral disease is a main source of morbidity(MM) in individuals with multiple myeloma. The effects of associated osteolytic lesions and vertebral fractures on severe pain, functional limits, spinal deformity, and cord compression are well recognized. Systemic therapy, radiation, cementoplasty (vertebroplasty/kyphoplasty), and radio frequency ablation are now available therapeutic options for severe MM spinal pain.

Case Presentation : We here reported a case of a 45-year-old male who had complained of progressive symptoms of pathological spine fractures. He had been examined and investigated for the cause of lytic lesions and found to have multiple fractures in the spine. A computed tomography (CT)revealed multiple osteolytic lesions noted in the thoracolumbar spine, ribs (bilaterally), and pelvic bones. Magnetic resonance imaging (MRI)showed a compression fracture of the T8 vertebral body with evidence of retro-bulging and a spinal canal narrowing. However, there was no evidence of spinal cord abnormal signal intensity. T2 weighted image (T2WI) keeping with edema is noted. A surgical intervention fixed the fracture and improved the quality of life. Vertebroplasty, a minimally invasive procedure, as a treatment option for vertebral lesions and pathologic fractures in the MM

Conclusion: Management of multiple myeloma spine metastases is an example of an inter professional, multidisciplinary, and comprehensive approach. Early diagnosis is the mainstay for a favorable outcome after the treatment. Vertebroplasty, as indicated, should be performed as early as possible. Vertebroplasty improves the quality of life, gives vital outcomes, and minimizes complications. Spinal cord compression is one of the worst side effects of multiple myeloma, and the best therapeutic approach is still up for debate. The authors attempted to offer a therapy plan for the best clinical outcomes by reviewing cases with various clinical courses and pertinent literature. Close examination of the mechanical stability and neurologic condition, as well as a multidisciplinary approach, are crucial for effective out comes in this systemic disease.